{"id":110600,"date":"2018-05-07T12:00:26","date_gmt":"2018-05-07T11:00:26","guid":{"rendered":"https:\/\/www.transcend.org\/tms\/?p=110600"},"modified":"2018-05-06T14:16:58","modified_gmt":"2018-05-06T13:16:58","slug":"big-pharma-wants-people-on-antidepressants-for-years-and-its-working","status":"publish","type":"post","link":"https:\/\/www.transcend.org\/tms\/2018\/05\/big-pharma-wants-people-on-antidepressants-for-years-and-its-working\/","title":{"rendered":"Big Pharma Wants People on Antidepressants for Years and It\u2019s Working"},"content":{"rendered":"

30 Apr 2018 – <\/em>Antidepressants were once considered a short-term therapy to help people get over a troubled time. All that changed with the debut of selective serotonin reuptake inhibitor (SSRI) antidepressants<\/a>, drug ads on TV, and the promotion of the \u201cchemical imbalance\u201d theory of depression. Though there is almost no evidence of the theory\u2013\u2013that SSRI antidepressants correct deficits in brain levels of serotonin, a neurotransmitter\u2013\u2013antidepressants became blockbusters for Pharma.<\/p>\n

\"\"<\/a>

Prozac vs Zoloft \u2013 Drug Details<\/p><\/div>\n

\u201cBy the mid-1990s, drug makers had convinced government regulators that when taken long-term, the medications sharply reduced the risk of relapse in people with chronic, recurrent depression,\u201d says the\u00a0New York Times<\/a>.<\/p>\n

Thanks to drug advertising and the unproven serotonin theory, the use of antidepressants has almost\u00a0tripled<\/a>. Only 13.4 million Americans took antidepressants in 1999\u20132000 ballooning to 34.4 million in 2013\u20134. In 2015 one in\u00a0four U.S. women<\/a> were on psychiatric drugs, usually antidepressants. More concerning, long-term use of antidepressants has doubled since 2010 and\u00a0tripled<\/em> since 2000 so that 15.5 million Americans have been taking the medications for at least five years. Yet few studies show the safety or efficacy antidepressants used long-term.<\/p>\n

I have frequently reported on the side effects of SSRIs from birth defects<\/a> associated with Paxil, including heart malformations, to sexual dysfunction<\/a> and weight gain. The pills are also linked to\u00a0serotonin syndrome<\/a> when taken with migraine drugs and gastrointestinal bleeding when taken with aspirin.<\/p>\n

One especially concerning side effect of SSRIs is\u00a0bone-thinning<\/a> and osteoporosis. Fracture events linked to SSRIs, especially from long-term use, have barely been researched or explored and are often dismissed by older patients as mere \u201caging.\u201d<\/p>\n

The wide use of SSRIs in the U.S. population does not just have health implications\u2014it has political implications, too. By selling \u201cdepression\u201d and its \u201ccure,\u201d Pharma siphons off legitimate, activist anger at a government system that keeps people poor, powerless, locked out of opportunity and saddled with debt. If they are unhappy, they have a\u00a0personal problem <\/em>says Pharma, treated with a pill\u2013\u2013not a political problem.<\/p>\n

Labeling bad and sad moods \u201cdepression\u201d also transmits an unrealistic idea that people should be \u201cmore than happy\u201d all the time and if they are not, they are \u201cmentally ill.\u201d Gone are the days when bad moods were attributed to problems with finance, romance, debt, jobs, housing, careers, family, marriages and health.<\/p>\n

Pharma backlash<\/strong><\/p>\n

In April, the New York Times\u00a0reported<\/a> something the drug safety community has warned about for years: antidepressants can be very difficult to quit. In fact, the withdrawal from them\u2013\u2013which Pharma calls a \u201cdiscontinuation syndrome\u201d\u2013\u2013is similar to that of addictive drugs. Many patients are miffed that they were not warmed by their doctors they may be \u201cparked\u201d on the drugs indefinitely, said the Times, thanks to side effects of dizziness, nausea, headache and brain zaps which do not go away quickly when they try to stop the drugs. Brian, a 29-year-old Chicagoan I interviewed who did not want his name used, told me he has remained on a SSRI antidepressant for years despite his wish to quit. \u201cEvery time I try to stop, I get something that feels like an electrical current in my head and I can\u2019t do it,\u201d he says.<\/p>\n

The article drew a\u00a0huge backlash<\/a> from psychiatrists from Pharma-funded medical schools. \u201cBy amplifying the social media echo chamber, the article creates the unfortunate impression that most patients are forced to continue antidepressants out of fear of withdrawal rather than out of prevention of recurrence,\u201d wrote 39 psychiatrists, terming depression \u201cchronic\u201d and \u201cundertreated.\u201d<\/p>\n

At least 35 of the letter signers who want to see more not less SSRIs are affiliated with Columbia University\u2019s College of Physicians and Surgeons which\u00a0received<\/a> $250 million from former Merck CEO Roy Vagelos and his wife Diana last year.<\/p>\n

There was a similar Pharma-funded\u00a0backlash<\/a> in 2004 when the FDA added a black box warning label to SSRIs that said they are linked to suicide, especially in young people, threatening drug sales.<\/p>\n

\u201cThe concerns about antidepressant use in children and adolescents have paradoxically resulted in a reduction in their use, and this has contributed to increased suicide rates,\u201d said Charles Nemeroff who happened to have links to Eli Lilly, Pfizer, Wyeth-Ayerst, Pharmacia-Upjohn and five other drug makers. Black box warnings create a barrier to treatment \u201cby scaring young people and parents away from care,\u201d said Mental Health America, reported to have accepted $3.8 million from pharmaceutical companies in 2005 the year after the black box warnings.<\/p>\n

Doctors promoting SSRIs in medical articles have also been\u00a0outed<\/a> as taking money from Pharma. Doctor authors who had defended the use of antidepressants during pregnancy in a 2006 Journal of the American Medical Association (JAMA) article had ties to antidepressant manufacturers. Lee Cohen, lead author of the antidepressants study, declared in a follow-up letter to JAMA that, \u201cWe did not view those associations as relevant to this study,\u201d and listed 76 other relationships the nine physician authors had with Pharma. Yes, 76. Three years later\u00a0another JAMA author was found to have undisclosed financial links to SSRI makers. Robert Robinson, who wrote about the drug Lexapro, had failed to\u00a0report lecture fees<\/a> he received from its manufacturer.<\/p>\n

Martin Keller, former professor emeritus of psychiatry at Brown and lead author of a now discredited Paxil study,\u00a0admitted<\/a> that GSK had given him tens of thousands of dollars during and after the study.<\/p>\n

Environmental concerns<\/strong><\/p>\n

Finally, with as much as a quarter of the population on SSRIs in some areas, there is an underreported concern about drugs in waterways<\/a> and even drinking systems. A few years ago, the Southern Daily Echo News\u00a0reported<\/a> that fish were under the influence of Prozac and five times more likely to swim toward light than away from it, making them also more susceptible to predators.<\/p>\n

Shrimp are also believed to be at risk. \u201dCrustaceans are crucial to the food chain and if shrimps\u2019 natural behaviour is being changed because of antidepressant levels in the sea this could seriously upset the natural balance of the ecosystem,\u201d says Dr. Alex Ford, from the University of Portsmouth\u2019s Institute of Marine Sciences.<\/p>\n

Could those of us who do not want to take psychiatric drugs be unwittingly receiving SSRIs anyway, perhaps in\u00a0drinking<\/a> water? \u201cThere\u2019s no doubt about it, pharmaceuticals are being detected in the environment and there is genuine concern that these compounds, in the small concentrations that they\u2019re at, could be causing impacts to human health or to aquatic organisms,\u201d said Mary Buzby, director of environmental technology for Merck. Clearly, Pharma\u2019s SSRI marketing spree which has millions of people on SSRIs for decades does not just threaten patients.<\/p>\n

_______________________________________________<\/p>\n

Martha Rosenberg is a freelance journalist and the author of the highly acclaimed, <\/em>Born with a Junk Food Deficiency: How Flaks, Quacks and Hacks Pimp the Public Health, published by Prometheus Books.<\/em><\/p>\n

Go to Original \u2013 intrepidreport.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

30 Apr 2018 – Antidepressants were once considered a short-term therapy to help people get over a troubled time. All that changed with the debut of selective serotonin reuptake inhibitor antidepressants, drug ads on TV, and the promotion of the \u201cchemical imbalance\u201d theory of depression.<\/p>\n","protected":false},"author":4,"featured_media":110601,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[52],"tags":[],"class_list":["post-110600","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"_links":{"self":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/posts\/110600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/comments?post=110600"}],"version-history":[{"count":0,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/posts\/110600\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/media\/110601"}],"wp:attachment":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/media?parent=110600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/categories?post=110600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/tags?post=110600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}