{"id":127171,"date":"2019-02-04T12:00:53","date_gmt":"2019-02-04T12:00:53","guid":{"rendered":"https:\/\/www.transcend.org\/tms\/?p=127171"},"modified":"2019-02-01T13:35:34","modified_gmt":"2019-02-01T13:35:34","slug":"alzheimers-is-linked-to-gum-disease-but-bad-oral-health-is-not-the-only-culprit","status":"publish","type":"post","link":"https:\/\/www.transcend.org\/tms\/2019\/02\/alzheimers-is-linked-to-gum-disease-but-bad-oral-health-is-not-the-only-culprit\/","title":{"rendered":"Alzheimer\u2019s Is Linked to Gum Disease \u2013 But Bad Oral Health Is Not the Only Culprit"},"content":{"rendered":"
\"\"<\/a>

shutterstock<\/p><\/div>\n

30 Jan 2019 – <\/em>For most people, teeth cleaning may just be a normal part of your daily routine. But what if the way you clean your teeth today, might affect your chances of getting Alzheimer\u2019s disease in years to come?<\/p>\n

There is an increasing body of evidence<\/a> to indicate that gum (periodontal) disease could be a plausible risk factor for Alzheimer\u2019s disease. Some studies<\/a> even suggest your risk doubles when gum disease persists for ten or more years. Indeed, a new US study published in Science Advances<\/a> details how a type of bacteria called Porphyromonas gingivalis<\/em> \u2013 or P. gingivalis<\/em> \u2013 which is associated with gum disease, has been found in the brains of patients with Alzheimer\u2019s disease. Tests on mice also showed how the bug spread from their mouth to brain where it destroyed nerve cells.<\/p>\n

The report in question was carried out and self-funded by founders of a US pharmaceutical company Cortexyme<\/a>, which is researching the cause of Alzheimer\u2019s and other degenerative disorders. Scientists from the San Francisco drug firm will launch a human trial later this year.<\/p>\n

What is gum disease?<\/strong><\/p>\n

The first phase of gum disease is called gingivitis. This occurs when the gums become inflamed in response to the accumulation of bacterial plaque on the surface of the teeth.<\/p>\n

Gingivitis is experienced by up to half of all adults but is generally reversible. If gingivitis is left untreated, \u201csub-gingival pockets\u201d form between the tooth and gum, which are filled by bacteria. These pockets indicate that gingivitis has converted to periodontitis. At this stage, it becomes almost impossible to eliminate the bacteria, though dental treatment can help control their growth.<\/p>\n

\"\"<\/a>

Brushing your teeth at least twice a day and flossing regularly can help to keep gum disease at bay. Shutterstock<\/p><\/div>\n

The risks of gum disease are significantly increased in people with poor oral hygiene. And factors such as smoking, medication, genetics, food choices, puberty and pregnancy can all contribute towards the development of the condition.<\/p>\n

Though it is important to remember that gum disease is not just the work of P. gingivalis<\/em> alone. A group of organisms including Treponema denticola<\/em>, Tanerella forsythia<\/em> and other bacteria also play a role in this complex oral disease.<\/p>\n

Mouth brain connection<\/strong><\/p>\n

At the University of Central Lancashire, we were the first to make the connection<\/a> with P. gingivalis<\/em> and fully diagnosed Alzheimer\u2019s disease. Subsequent studies<\/a> have also found this bacteria \u2013 which is responsible for many forms of gum disease \u2013 can migrate from the mouth to the brain in mice. And on entry to the brain, P. gingivalis<\/em> can reproduce all of the characteristic features of Alzheimer\u2019s disease.<\/p>\n

\"\"<\/a>

Having good dental hygiene, a healthy low sugar diet and regular dental checks up can help prevent gum disease. Shutterstock<\/p><\/div>\n

The recent US research which found the bacteria of chronic gum disease in the brains of Alzheimer\u2019s disease patients gives additional very strong research-based evidence \u2013 but it must be interpreted in context. And the fact of the matter is that Alzheimer\u2019s disease is linked with a number of other conditions<\/a> and not just gum disease.<\/p>\n

Existing research<\/a> shows that other types of bacteria and the Herpes type I virus<\/a> can also be found in Alzheimer\u2019s disease brains. People with Down\u2019s syndrome are also at a higher risk<\/a> of developing Alzheimer\u2019s disease, as are people who have had a severe head injury. Research also shows that several conditions associated with cardiovascular disease can increase the risk of Alzheimer\u2019s disease. This suggests there are many causes with one endpoint \u2013 and scientists are still trying to figure out the connection.<\/p>\n

This endpoint results in the same symptoms of Alzheimer\u2019s: poor memory and behavioural changes. This also occurs alongside plaque buildup in the grey matter of the brain and what\u2019s known as \u201cneurofibrillary tangles\u201d. These are the debris left from the collapse of a neuron\u2019s internal skeleton. These occur when a protein can no longer perform its function of stabilising the cell structure.<\/p>\n

Brush your teeth<\/strong><\/p>\n

The latest research adds more evidence to the theory that gum disease is one of the things that can lead to Alzheimer\u2019s disease. But before you start panic brushing your teeth, it\u2019s important to remember that not everyone who suffers from gum disease develops Alzheimer\u2019s disease and not all who suffer from Alzheimer\u2019s disease have gum disease.<\/p>\n

To find out who is \u201cat risk\u201d, scientists now need to develop tests that can show the dentist who to target. Dental clinicians can then advise those people as to how they can reduce the risk of developing Alzheimer\u2019s disease through better management of their oral health. But until then, regularly brushing your teeth and maintaining good oral hygeine<\/a> is recommended.<\/p>\n

_________________________________________<\/em><\/p>\n

\"\"<\/a><\/em><\/p>\n

Sim K. Singhrao <\/a>– Senior Research Fellow in the School of Dentistry, University of Central Lancashire <\/em><\/p>\n

 <\/p>\n

 <\/p>\n

Republish our articles for free, online or in print, under Creative Commons license.<\/em><\/p>\n

Go to Original \u2013 theconversation.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

30 Jan 2019 – We were the first to make the connection between P. gingivalis and fully diagnosed Alzheimer\u2019s disease. While evidence of a link is growing, it must be interpreted in context.<\/p>\n","protected":false},"author":4,"featured_media":127172,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[52],"tags":[],"class_list":["post-127171","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"_links":{"self":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/posts\/127171","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/comments?post=127171"}],"version-history":[{"count":0,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/posts\/127171\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/media\/127172"}],"wp:attachment":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/media?parent=127171"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/categories?post=127171"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/tags?post=127171"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}