{"id":177287,"date":"2021-01-18T12:01:32","date_gmt":"2021-01-18T12:01:32","guid":{"rendered":"https:\/\/www.transcend.org\/tms\/?p=177287"},"modified":"2021-08-02T04:35:54","modified_gmt":"2021-08-02T03:35:54","slug":"vaccines-alone-arent-enough-to-eradicate-a-virus-lessons-from-history","status":"publish","type":"post","link":"https:\/\/www.transcend.org\/tms\/2021\/01\/vaccines-alone-arent-enough-to-eradicate-a-virus-lessons-from-history\/","title":{"rendered":"Vaccines Alone Aren\u2019t Enough to Eradicate a Virus \u2013 Lessons from History"},"content":{"rendered":"
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Dryvax, smallpox vaccine with bifurcated needle.
James Gathany Content Providers\/CDC Public Health Image Library<\/p><\/div>\n

14 Jan 2021 – <\/em>Smallpox killed countless millions \u2013 300 million people in the 20th century alone \u2013 before it was finally declared eradicated on May 8 1980. It was a momentous day, marking what the current director general of the World Health Organization, Dr Tedros Adhanom Ghebreyesus, called the greatest \u201cpublic health triumph in world history\u201d<\/a>.<\/p>\n

Smallpox, as one researcher has emphasised<\/a>, \u201cwas eradicated solely through vaccination\u201d. Today, this achievement feels particularly encouraging and seems ready for a reboot as governments worldwide tell the public that the COVID vaccine will soon end the pandemic and return life to normal.<\/p>\n

Worldwide, advance reviews are flooding in. Vaccines are a \u201clight at the end of the tunnel\u201d<\/a>, our ticket to \u201cnormality\u201d<\/a>. They have brought a \u201creal end\u201d<\/a> into sight. From New York governor Andrew Cuomo came the inevitable military analogy: the vaccine was no less than \u201cthe weapon that is going to win the war\u201d<\/a>.<\/p>\n

The current vaccination campaigns are not attempting to eradicate SARS-CoV-2, the virus that causes COVID. But, based on the history of smallpox vaccination, even the much lower bar of herd immunity will be difficult to clear if we pin so much of our hope on vaccination.<\/p>\n

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Although the eradication of smallpox is often held up as proof of the definitive success of vaccines, it should not be forgotten that smallpox raged for centuries before it was finally brought to an end. One of the first steps towards eradication took place in 1796 when, as the somewhat apocryphal story<\/a> goes, Edward Jenner injected pus extracted from a dairymaid\u2019s cowpox lesion into the arm of his gardener\u2019s eight-year-old son.<\/p>\n

\"Painting
Edward Jenner performing his first vaccination on James Phipps, an eight-year-old boy.<\/span> Wellcome\/Wikimedia Commons<\/a><\/span><\/figcaption><\/figure>\n

The following 150 years were marked by concern<\/a> about the vaccine\u2019s efficacy, safety and side-effects. As late as 1963, British doctors<\/a> were still alarmed by the slow uptake of routine smallpox vaccination, warning that this \u201cindifference\u201d would require a \u201cvast programme of re-education\u201d.<\/p>\n

Hesitancy was not the only problem. Well into the 20th century, vaccines were unequally distributed around the globe, and periodic outbreaks ensured that smallpox remained endemic in much of the world, particularly in developing countries.<\/p>\n

By 1967, when the WHO launched the ten-year intensified smallpox eradication programme<\/a>, four other eradication efforts (hookworm, yellow fever, yaws and malaria) had already failed, and many involved in such programmes had become sceptical about eradication as a goal at all. Indeed, the 1966 director general of the WHO, Marcelino Candau, believed that disease eradication was simply not possible.<\/p>\n

What they had come to realise was that vaccines alone are not enough to contain or eradicate a disease. Instead, it would be essential to combine technological developments \u2013 such as the introduction of heat-stable freeze-dried vaccines and the bifurcated (two-pronged) needle \u2013 with efforts such as surveillance, case finding, contact tracing, ring vaccination (controlling an outbreak by vaccinating a ring of people around each infected individual), and communication campaigns to find, track and inform affected people.<\/p>\n

This sort of programme would encounter various challenges from funding to political strife to cultural practices and norms. It would also cost a whopping 20% of the WHO\u2019s budget and take a decade of intensive labour \u2013 and come at the expense of other, more basic healthcare interventions. But eventually it succeeded. Smallpox, outside of the lab at least<\/a>, was gone.<\/p>\n

All this time and coordinated effort, even though smallpox was in some ways an ideal candidate for eradication<\/a>. For one thing, its symptoms were so obvious that it was easy to identify and track, and so also easier to contain. And smallpox was a disease unique to humans, affecting no other animals. Its eradication from human populations was its eradication from the planet.<\/p>\n

Low-tech public health strategies<\/h2>\n

The history of smallpox eradication makes it apparent that high-tech vaccinations only work when they are effectively combined with low-tech public health strategies. These low-tech strategies include isolation and quarantine, and especially tracking and tracing, as well as the increasingly elusive elements of public trust and effective communication.<\/p>\n

Perhaps most clearly, the smallpox story shows that the control of COVID requires a global effort that attends to local needs. This is partly an ethical imperative, partly a practical one. We live in a world with remarkably porous borders, even in times of lockdown. If the smallpox eradication programme has taught us anything, it\u2019s that lasting reprieve from pandemic disease is difficult, if not impossible, to achieve if nations insist on acting in seclusion.<\/p>\n

The glorification of the COVID vaccines follows a well-worn track in its presumption that the arrival of a vaccine heralds the pandemic\u2019s end. Yet in the case of smallpox, our most successful vaccine story to date, this has required the glossing over of centuries of suffering and death and the intense public health struggle to contain the disease. Vaccination did not end smallpox. That was done by a small army of people and organisations working intensively and cooperatively across the globe, inventing and improvising a series of public health measures.<\/p>\n

We have inherited a recent medical and political past that values quick fixes and cures, blindly embracing these to the exclusion of the messy details of how healthcare actually works. It is not just the final eradication of smallpox, then, but also the personal and public health havoc it wreaked across the centuries that should guide our efforts. For these supply the context we need to create reasonable expectations about what the end of our current pandemic might look like and what it will take to get there.<\/p>\n<\/div>\n

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