{"id":182571,"date":"2021-04-12T12:00:53","date_gmt":"2021-04-12T11:00:53","guid":{"rendered":"https:\/\/www.transcend.org\/tms\/?p=182571"},"modified":"2021-04-09T05:36:54","modified_gmt":"2021-04-09T04:36:54","slug":"could-mrna-vaccines-permanently-alter-dna-recent-science-suggests-they-might","status":"publish","type":"post","link":"https:\/\/www.transcend.org\/tms\/2021\/04\/could-mrna-vaccines-permanently-alter-dna-recent-science-suggests-they-might\/","title":{"rendered":"Could mRNA Vaccines Permanently Alter DNA? Recent Science Suggests They Might"},"content":{"rendered":"
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Research on SARS-CoV-2 RNA by scientists at Harvard and MIT has implications for how mRNA vaccines could permanently alter genomic DNA, according to Doug Corrigan, Ph.D., a biochemist-molecular biologist who says more research is needed.<\/em><\/p>\n<\/blockquote>\n

\"\"<\/a><\/p>\n

8 Apr 2021 – <\/em>Over the past year, it would be all but impossible for Americans not to notice the media\u2019s decision to make vaccines the dominant COVID narrative, rushing to do so even before<\/a> any coronavirus-attributed deaths occurred.<\/p>\n

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The media\u2019s slanted coverage has provided a particularly fruitful public relations boost for messenger RNA<\/a> (mRNA) vaccines \u2014 decades in the making<\/a> but never approved for human use \u2014 helping to usher the experimental<\/a> technology closer to the regulatory finish line.<\/p>\n

Under ordinary circumstances, the body makes (\u201ctranscribes\u201d) mRNA<\/a> from the DNA in a cell\u2019s nucleus. The mRNA then travels out of the nucleus into the cytoplasm<\/a>, where it provides instructions about which proteins to make.<\/p>\n

By comparison, mRNA vaccines send their chemically synthesized<\/a> mRNA payload (bundled with spike protein-manufacturing instructions) directly into the cytoplasm.<\/p>\n

According to the Centers for Disease Control and Prevention (CDC) and most mRNA vaccine scientists<\/a>, the buck then stops there \u2014 mRNA vaccines \u201cdo not affect or interact with<\/a> our DNA in any way,\u201d the CDC says. The CDC asserts first, that the mRNA cannot enter the cell\u2019s nucleus (where DNA resides), and second, that the cell \u2014 Mission-Impossible-style \u2014 \u201cgets rid of the mRNA soon after it is finished using the instructions.\u201d<\/p>\n

A December preprint<\/a> about SARS-CoV-2<\/a>, by scientists at Harvard and Massachusetts Institute of Technology (MIT), produced findings about wild coronavirus that raise questions about how viral RNA operates.<\/p>\n

The scientists conducted the analysis<\/a> because they were \u201cpuzzled<\/a> by the fact that there is a respectable number of people who are testing positive for COVID-19 by PCR<\/a> long after the infection was gone.\u201d<\/p>\n

Their key findings were as follows: SARS-CoV-2 RNAs \u201ccan be reverse transcribed in human cells,\u201d \u201cthese DNA sequences can be integrated into the cell genome and subsequently be transcribed\u201d (a phenomenon called \u201cretro-integration\u201d) \u2014 and there are viable cellular pathways to explain how this happens.<\/p>\n

According to Ph.D. biochemist and molecular biologist Dr. Doug Corrigan<\/a>, these important findings (which run contrary to \u201ccurrent biological dogma\u201d) belong to the category<\/a> of \u201cThings We Were Absolutely and Unequivocally Certain Couldn\u2019t Happen Which Actually Happened.\u201d<\/p>\n

The findings of the Harvard and MIT researchers also put the CDC\u2019s assumptions about mRNA vaccines on shakier ground, according to Corrigan.\u00a0In fact, a month before the Harvard-MIT preprint appeared, Corrigan had already written a blog outlining<\/a> possible mechanisms and pathways whereby mRNA vaccines could produce the identical phenomenon.<\/p>\n

In a second blog post<\/a>, written after the preprint came out, Corrigan emphasized that the Harvard-MIT findings about coronavirus RNA have major implications for mRNA vaccines \u2014 a fact he describes as \u201cthe big elephant in the room.\u201d While not claiming that vaccine RNA will necessarily behave in the same way as coronavirus RNA \u2014 that is, permanently altering genomic DNA \u2014 Corrigan believes<\/a> that the possibility exists and deserves close scrutiny.<\/p>\n

In Corrigan\u2019s view, the preprint\u2019s contribution is that it \u201cvalidates that this is at least plausible, and most likely probable<\/a>.\u201d<\/p>\n

Reverse transcription<\/strong><\/p>\n

As the phrase \u201creverse transcription\u201d implies, the DNA-to-mRNA pathway is not always a one-way street. Enzymes called reverse transcriptases can also convert RNA into DNA<\/a>, allowing the latter to be integrated into the DNA in the cell nucleus.<\/p>\n

Nor is reverse transcription uncommon. Geneticists report that \u201cOver 40%<\/a> of mammalian genomes comprise the products of reverse transcription.\u201d<\/p>\n

The preliminary evidence<\/a> cited by the Harvard-MIT researchers indicates that endogenous reverse transcriptase enzymes may facilitate reverse transcription of coronavirus RNAs and trigger their integration into the human genome.<\/p>\n

The authors suggest that while the clinical consequences<\/a> require further study, detrimental effects are a distinct possibility and \u2014 depending on the integrated viral fragments\u2019 \u201cinsertion sites in the human genome\u201d and an individual\u2019s underlying health status \u2014 could include \u201ca more severe immune response \u2026 such as a \u2018cytokine storm<\/a>\u2019 or auto-immune reactions.\u201d<\/p>\n

In 2012, a study suggested<\/a> that viral genome integration could \u201clead to drastic consequences for the host cell, including gene disruption, insertional mutagenesis and cell death.\u201d<\/p>\n

Corrigan makes a point of saying that the pathways<\/a> hypothesized to facilitate retro-integration of viral \u2014 or vaccine \u2014 RNA into DNA \u201care not unknown to people who understand molecular biology at a deeper level.\u201d<\/p>\n

Even so, the preprint\u2019s discussion of reverse transcription and genome integration elicited a maelstrom of negative comments<\/a> from readers unwilling to rethink biological dogma, some of whom even advocated for retraction (though preprints are, by definition, unpublished) on the grounds that \u201cconspiracy theorists \u2026 will take this paper to \u2018proof\u2019 that mRNA vaccines can in fact alter your genetic code.\u201d<\/p>\n

More thoughtful readers agreed with Corrigan that the paper raises important questions. For example, one reader stated that confirmatory evidence is lacking \u201cto show that the spike protein only is expressed for a short amount of time (say 1-3 days) after vaccination,\u201d adding, \u201cWe think that this is the case, but there is no evidence for that.\u201d<\/p>\n

In fact, just how long the vaccines\u2019 synthetic mRNA \u2014 and thus the instructions for cells to keep manufacturing spike protein \u2014 persist inside the cells is an open question.<\/p>\n

Ordinarily, RNA is a \u201cnotoriously fragile<\/a>\u201d and unstable molecule. According to scientists, \u201cthis fragility is true of the mRNA of any living thing<\/a>, whether it belongs to a plant, bacteria, virus or human.\u201d<\/p>\n

But the synthetic mRNA in the COVID vaccines<\/a> is a different story. In fact, the step that ultimately allowed scientists and vaccine manufacturers to resolve<\/a> their decades-long mRNA vaccine impasse was when they figured out how to chemically modify<\/a> mRNA to increase its stability and longevity \u2014 in other words, produce RNA \u201cthat hangs around in the cell much longer<\/a> than viral RNA, or even RNA that our cell normally produces for normal protein production.\u201d<\/p>\n

It is anyone\u2019s guess what the synthetic mRNA is doing while it is \u201changing around,\u201d but Corrigan speculates that its enhanced longevity raises the probability<\/a> of it \u201cbeing converted over into DNA.\u201d<\/p>\n

Moreover, because the vaccine mRNA is also engineered to be more efficient at being translated into protein, \u201cnegative effects could be more frequent and more pronounced with the vaccine<\/a> when compared to the natural virus.\u201d<\/p>\n

Dollar signs<\/strong><\/p>\n

Corrigan acknowledges that some people may dismiss his warnings, saying \u201cIf the virus is able to accomplish this, then why should I care if the vaccine does the same thing?\u201d<\/p>\n

He has a ready and compelling response:<\/p>\n

\u201c[T]here\u2019s a big difference between the scenario where people randomly, and unwittingly, have their genetics monkeyed with because they were exposed to the coronavirus, and the scenario where we willfully vaccinate billions of people while telling them this isn\u2019t happening.\u201d<\/em><\/p><\/blockquote>\n

Unfortunately, the prevailing attitude seems to be that the \u201crace to get the public vaccinated\u201d justifies taking these extra risks<\/a>.<\/p>\n

In mid-November, after the Jerusalem Post<\/a> told readers that \u201cwhen the world begins inoculating itself with these completely new and revolutionary vaccines, it will know virtually nothing about their long-term effects,\u201d an Israeli hospital director argued that it\u2019s not worth waiting two more years to ferret out mRNA vaccines\u2019 \u201cunique and unknown risks\u201d or potential long-term effects.<\/p>\n

In the U.S., enthusiasm for mRNA technology is similarly unfettered. Just a few days after the CDC released updated data<\/a> showing that more than 2,200 deaths of individuals who had received either the Pfizer<\/a> or Moderna<\/a> mRNA vaccines had been reported as of Mar. 26 , The Atlantic praised the technology<\/a>, suggesting that the \u201cingenious\u201d synthetic mRNA technology behind Pfizer\u2019s and Moderna\u2019s COVID vaccines represented a \u201cbreakthrough\u201d that could \u201cchange the world.\u201d<\/p>\n

Rather than dismiss the prospect of retro-integration of foreign DNA as a \u201cconspiracy theory,\u201d scientists should be conducting studies with the mRNA-vaccinated to assess actual risks.<\/p>\n

For example, Corrigan believes that while in vitro data in human cell lines (one of the data sources examined by the Harvard-MIT researchers) offer \u201cair tight\u201d results, there is still a need to conclusively demonstrate real-life genomic alteration through \u201cPCR, DNA sequencing or Southern Blot<\/a> \u2026 on purified genomic DNA of COVID-19 patients\u201d \u2014 and vaccinated individuals.<\/p>\n

Yet instead of addressing these research gaps, companies are salivating over the potential<\/a> to use human-edited mRNA to \u201ccommandeer our cellular machinery\u201d and \u201cmake just about any protein under the sun.\u201d<\/p>\n

A March 10 press release<\/a> pronouncing mRNA vaccines the clear winners of the COVID-19 vaccine race noted that all major pharmaceutical<\/a> companies are now \u201ctesting out the [mRNA] technology by entering into license agreements and\/or collaboration with well-established RNA companies.\u201d<\/p>\n

In old Disney cartoons, viewers often witnessed Donald Duck\u2019s rich uncle, Scrooge McDuck\u2019s, \u201cbulging eyes [turn] into oversized Vegas slot machine dollar signs<\/a>\u201d when contemplating opportunities to increase his already immense wealth.<\/p>\n

Judging by pharmaceutical company executives\u2019 willingness to overlook mRNA vaccines\u2019 long-term \u2014 and possibly multigenerational \u2014 risks, they must be similarly entranced by dollar-sign visions of a never-ending pipeline of \u201cplug and play<\/a>\u201d mRNA products.<\/p>\n

Go to Original – childrenshealthdefense.org<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

8 Apr 2021 – Research on SARS-CoV-2 RNA by scientists at Harvard and MIT has implications for how mRNA vaccines could permanently alter genomic DNA, according to Doug Corrigan, Ph.D., a biochemist-molecular biologist who says more research is needed.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2124],"tags":[1829,1868,932,1055,1864,888],"class_list":["post-182571","post","type-post","status-publish","format-standard","hentry","category-debates-on-covid-vaccines","tag-coronavirus","tag-covid-19","tag-genetic-engineering","tag-genetic-manipulation","tag-pandemic","tag-vaccines"],"_links":{"self":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/posts\/182571","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/comments?post=182571"}],"version-history":[{"count":0,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/posts\/182571\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/media?parent=182571"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/categories?post=182571"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/tags?post=182571"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}