{"id":85508,"date":"2017-01-16T12:00:35","date_gmt":"2017-01-16T12:00:35","guid":{"rendered":"https:\/\/www.transcend.org\/tms\/?p=85508"},"modified":"2017-01-16T11:28:37","modified_gmt":"2017-01-16T11:28:37","slug":"poison-fruit-dow-chemical-wants-farmers-to-keep-using-a-pesticide-linked-to-autism-and-adhd","status":"publish","type":"post","link":"https:\/\/www.transcend.org\/tms\/2017\/01\/poison-fruit-dow-chemical-wants-farmers-to-keep-using-a-pesticide-linked-to-autism-and-adhd\/","title":{"rendered":"Poison Fruit: Dow Chemical Wants Farmers to Keep Using a Pesticide Linked to Autism and Attention Deficit Hyperactivity Disorder"},"content":{"rendered":"<div id=\"attachment_85509\" style=\"width: 710px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ.jpg\" ><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-85509\" class=\"wp-image-85509\" src=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ-1024x512.jpg\" width=\"700\" height=\"350\" srcset=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ-1024x512.jpg 1024w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ-300x150.jpg 300w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ-768x384.jpg 768w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ.jpg 1440w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><p id=\"caption-attachment-85509\" class=\"wp-caption-text\">Photo: David Paul Morris\/Bloomberg News\/Getty Images<\/p><\/div>\n<p><em>14 Jan 2017 &#8211; <\/em>On Mondays, Magda and Amilcar Galindo take their daughter Eva to self-defense class. Eva is 12 but her trusting smile and arching pigtails make her look younger. Diagnosed with autism and attention deficit hyperactivity disorder, or ADHD, Eva doesn\u2019t learn or behave like the typical 12-year-old. She struggles to make change, and she needs help with reading and social situations. Eva\u2019s classmates are sometimes unkind to her, and Magda worries for her daughter\u2019s feelings and her safety. So once a week, after they drive her from her middle school in Modesto, California, to her tutor in nearby Riverbank, the Galindos rush off to the gym where they cheer Eva on as she wrestles with a heavy bag and punches the air with her skinny arms.<\/p>\n<div id=\"attachment_85510\" style=\"width: 310px\" class=\"wp-caption alignright\"><a href=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ2.jpg\" ><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-85510\" class=\"wp-image-85510\" src=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ2-728x1024.jpg\" width=\"300\" height=\"422\" srcset=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ2-728x1024.jpg 728w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ2-213x300.jpg 213w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ2-768x1080.jpg 768w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ2.jpg 941w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><p id=\"caption-attachment-85510\" class=\"wp-caption-text\">The Galindo family at home in Modesto, Calif.<br \/> Photo: Shaun Lucas for The Intercept<\/p><\/div>\n<p>The Galindos wish they could have protected their daughter from whatever originally caused her troubles, which began in infancy, when she screamed incessantly. As she got older, Eva was slow to talk and make friends. Nine years ago, when her pediatrician diagnosed her with autism, he told the Galindos that nobody really knew why children developed such problems. And in some ways, that is still true; both the causes of these neurodevelopmental conditions and their increase among American children remain mysterious.<\/p>\n<p>But a study the family participated in when Eva was 3\u00a0has pointed to one possible culprit: chlorpyrifos, a widely used pesticide that was sprayed near their home when Magda was pregnant. At the time, the family was living in Salida, a small town in central California surrounded by fields of almonds, corn, and peaches. The Galindos could see the planted fields just down the street from their stucco house. And Magda could smell them from the patio where she spent much of her pregnancy. Sometimes the distinct essence of cow manure filled the air. At other times she sniffed the must of fertilizer. And there was a third odor, too \u2014 \u201cthe smell of the chemical,\u201d said Galindo. \u201cYou can tell, it\u2019s different from mulch and manure. When they sprayed, the smell was different.\u201d<\/p>\n<p>In 2014, the first and most comprehensive look at the environmental causes of autism and developmental delay, known as the <a target=\"_blank\" href=\"http:\/\/beincharge.ucdavis.edu\/\" >CHARGE<\/a> <a target=\"_blank\" href=\"http:\/\/ehp.niehs.nih.gov\/wp-content\/uploads\/122\/10\/ehp.1307044.alt.pdf\" >study<\/a>, found that the nearby application of agricultural pesticides <a target=\"_blank\" href=\"http:\/\/ehp.niehs.nih.gov\/wp-content\/uploads\/122\/10\/ehp.1307044.alt.pdf\" >greatly increases the risk of autism<\/a>. Women who lived less than a mile from fields where chlorpyrifos was sprayed during their second trimesters of pregnancy, as Magda did, had their chances of giving birth to an autistic child more than triple. And it was just one of dozens of recent studies that have linked even small amounts of fetal chlorpyrifos exposure to neurodevelopmental problems, including ADHD, intelligence deficits, and learning difficulties.<\/p>\n<p>On November 10, the U.S. Environmental Protection Agency issued a groundbreaking report laying out\u00a0the serious dangers of chlorpyrifos. The \u201c<a target=\"_blank\" href=\"https:\/\/www.regulations.gov\/document?D=EPA-HQ-OPP-2015-0653-0454\" >Chlorpyrifos Revised Human Health Risk Assessment<\/a>,\u201d as it was called, laid out the evidence that the pesticide can cause intelligence deficits and attention, memory, and motor problems in children. According to the <a target=\"_blank\" href=\"https:\/\/www.regulations.gov\/document?D=EPA-HQ-OPP-2015-0653-0454\" >report<\/a>, 1-\u00a0and 2-year-old children risk exposures from food alone that are <a target=\"_blank\" href=\"https:\/\/www.nrdc.org\/experts\/miriam-rotkin-ellman\/epa-toxic-pesticide-fruitsveggies-puts-kids-risk\" >14,000 percent<\/a> above the level the agency now thinks is safe.<\/p>\n<p>Dow, the giant chemical company that patented chlorpyrifos and still makes most of the products containing it, has consistently disputed the mounting scientific evidence that its blockbuster chemical harms children. But the government report made it clear that the EPA now\u00a0accepts the independent science showing that the pesticide used to grow so much of our food is unsafe.\u00a0The \u201cpre-publication <a target=\"_blank\" href=\"https:\/\/www3.epa.gov\/pesticides\/PrePublicationCopy_16P-0280_2016-11-10.pdf\" >copy<\/a>\u201d of the report stated that \u201cresidues of chlorpyrifos on most individual food crops exceed the \u2018reasonable certainty of no harm\u2019 safety standard under the Federal Food, Drug and Cosmetic Act,\u201d which means, in simple terms, that any given sample of food may contain\u00a0harmful levels of chlorpyrifos. In addition, estimated drinking water and non-drinking water exposures to the chemical also\u00a0exceed safety standards. The next step was to finalize a chlorpyrifos ban.<\/p>\n<p>Public health advocates have been calling on the EPA to ban the pesticide for years. Four months before the report came out, a group of 47 scientists and doctors with expertise in children\u2019s brain development, including the director of the National Institute of Environmental Health Sciences, issued a grave warning that toxic chemicals in the environment were increasing children\u2019s risks of developing behavioral, cognitive, and social disorders and contributing to the rise in cases of autism and ADHD. The <a target=\"_blank\" href=\"http:\/\/ehp.niehs.nih.gov\/wp-content\/uploads\/124\/7\/EHP358.alt.pdf\" >TENDR statement<\/a>, as it was called, included a list of the worst neurotoxins and amounted to a desperate plea for immediate action. Organophosphate pesticides, the class of chemical to which chlorpyrifos belongs, was at the top of the list.<\/p>\n<p>Yet when the EPA\u2019s report was published indicating that the agency was finally taking action on chlorpyrifos, there was little rejoicing among the scientists and environmental advocates, because two days earlier, Donald Trump had won the presidential election.<\/p>\n<p>Although the new risk assessment was the missing puzzle piece necessary to get chlorpyrifos out of the food chain and water supply, the law requires a 60-day <a target=\"_blank\" href=\"https:\/\/www.regulations.gov\/document?D=EPA-HQ-OPP-2015-0653-0402\" >comment period<\/a> before such a decision can be finalized. Trump will be inaugurated three days after the <a target=\"_blank\" href=\"https:\/\/www.regulations.gov\/comment?D=EPA-HQ-OPP-2015-0653-0402\" >comment<\/a> period ends on January 17. The final deadline to incorporate the comments on the\u00a0report is March 31, 2017, giving the new administration almost two months to derail the long-awaited regulation.<\/p>\n<div id=\"attachment_85511\" style=\"width: 510px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ3.jpg\" ><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-85511\" class=\"wp-image-85511\" src=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ3-1024x744.jpg\" width=\"500\" height=\"363\" srcset=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ3-1024x744.jpg 1024w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ3-300x218.jpg 300w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ3-768x558.jpg 768w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ3.jpg 1884w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/a><p id=\"caption-attachment-85511\" class=\"wp-caption-text\">Eva Galindo reads a magazine on Dec. 29, 2016, in Modesto, Calif.<br \/> Photo: Shaun Lucas for The Intercept<\/p><\/div>\n<p>Chlorpyrifos is the \u201cCoca-Cola of growers,\u201d as one former staffer of California\u2019s Office of Pesticides described it to me. \u201cEveryone uses it out here.\u201d Across the country, some 44,000 American farms collectively use between 6 million and 10 million pounds of chlorpyrifos each year on everything from corn, soybeans, asparagus, and peaches to strawberries, broccoli, cauliflower, onions, walnuts, and cranberries. Used on more than half of all apples and broccoli sold in the U.S., chlorpyrifos makes its way into the vast majority of American kitchens. The chemical has also been found in 15 percent of water samples taken around the country between 1991 and 2012 by the U.S. Geological Survey\u2019s National Water Quality Assessment Program.<\/p>\n<p>Several farmers I spoke with at a Dow-sponsored citrus growers convention in Exeter, California, explained that they used <a target=\"_blank\" href=\"http:\/\/www.dowagro.com\/en-us\/usag\/product-solution-finder\/insecticides\/lorsbanadvanced\" >Lorsban<\/a>, one of Dow\u2019s chlorpyrifos-containing products, because it is one of the most reliable and affordable products available to kill ants. The growers were also clearly hoping\u00a0the pesticide, which kills some 400 different species, would\u00a0help combat the Asian citrus psyllid, a sap-sucking bug that has been killing fruit trees around the country.<\/p>\n<p>It\u2019s a testament to both the deference the government has shown\u00a0large companies and the lack of foresight about the consequences of spraying our food with toxic chemicals that the pesticide could become such a widely used tool. After all, there has never been much doubt that organophosphates harm people. German chemist Gerhard Schrader first documented the effects of the chemicals on the human nervous system while trying to develop pesticides to protect food for the Nazi war effort. As Schrader noted in 1936 after he and a colleague were severely sickened by a mere drop of organophosphate that landed on a lab bench near them, people who were exposed choked, shook, vomited, and sweated. Because exposure sometimes led to seizures, comas, and death, the discovery spawned the use of organophosphates as weapons and Schrader spent much of the war producing one of these first nerve agents, Tabun, at a secret Nazi lab.<\/p>\n<p>More than two decades later, the environmental writer Rachel Carson described the effects of organophosphate pesticides, or organic phosphorus insecticides, as she called them, in terms eerily similar to Schrader\u2019s in her 1962 bestseller, \u201cSilent Spring\u201d: \u201cTheir target is the nervous system, whether the victim is an insect or a warm-blooded animal. \u2026 The movements of the whole body become uncoordinated: tremors, muscular spasms, convulsions, and death quickly result.\u201d<\/p>\n<p>Even back then, the organophosphate pesticides that were supposed to focus their lethal power on cockroaches, ticks, ants, and termites were clearly triggering some of the same reactions in humans.<\/p>\n<p>Chlorpyrifos \u2014 and for that matter the nerve agents Sarin and Tabun \u2014 work by blocking cholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine. When cholinesterase doesn\u2019t function correctly, the nervous system can go into overdrive, as nerves fire repeatedly without being shut off. Thus, between being sprayed with organophosphates and dying, <a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2428034\/?page=3\" >cockroaches<\/a> become hyperactive, hyperexcitable, and convulse. And, as Carson delicately described back in 1962, \u201choneybees become wildly agitated and bellicose.\u201d<\/p>\n<p>Though it was introduced to the market in 1965, the use of chlorpyrifos in farming only began to take off in the 1980s after another group of chemicals was phased out because of the health problems they caused. Carson, who died of cancer at age 56, just 18 months after the publication of \u201cSilent Spring,\u201d would no doubt have been dismayed to know that the banning of DDT, for which she is often credited, gave rise to the widespread use of organophosphates, such as chlorpyrifos. Back in 1962, she already saw the folly of swapping one neurotoxic chemical for another and noted that DDT was itself a replacement for the pesticide lead arsenate, which was abandoned because it too had caused health problems.<\/p>\n<p>As the use of the pesticide rose, so did concerns about it. In 1988, Congress asked the National Academy of Sciences to look into whether pesticides in children\u2019s diets might be dangerous. The <a target=\"_blank\" href=\"https:\/\/www.nap.edu\/read\/2126\/chapter\/1#viii\" >resulting report<\/a> described a range of harms that pesticides can cause and noted that organophosphates have \u201csubtle and long-lasting neurobehavioral impairments\u201d in animals. When he was presenting the report to Congress in 1993, epidemiologist Philip Landrigan, who led the committee, warned that children were particularly vulnerable and <a target=\"_blank\" href=\"https:\/\/www.nap.edu\/read\/2126\/chapter\/1\" >called on Congress<\/a> to apply more stringent pesticide standards.<\/p>\n<p>The shorter-term dangers of the chemical were already apparent by 1996, when the annual number of chlorpyrifos poisonings, which can cause twitching, tremors, slurred speech, and even paralysis and death, reported to Poison Control Centers in the U.S. reached <a target=\"_blank\" href=\"http:\/\/www.ag.ny.gov\/press-release\/dow-subsidiary-pay-2-million-making-false-safety-claims-pesticide-ads\" >7,000<\/a>. It was also becoming clear that children were particularly sensitive to the pesticide, which was available in many household products used to kill cockroaches, termites, fleas, and other bugs.<\/p>\n<p>Vicki Herb learned that soon after she brought her infant son, Joshua, to her West Virginia home from the hospital. Joshua Herb had been born healthy in 1990. But days later an exterminator came for a regularly scheduled visit and, not noticing Joshua asleep in his crib, sprayed chlorpyrifos on a nearby windowsill while the baby was napping. Within days, Joshua became partially paralyzed. Though the doctors who first saw him were dismissive of the idea, Vicki Herb believed her son had been poisoned by pesticides and in 1992 hired attorney Stuart Calwell to sue Dow. Since then the evidence of its dangers \u2014 particularly to children \u2014 have been mounting.<\/p>\n<p>The Herbs\u2019 case, along with several others that Calwell brought against Dow, did more than reveal how powerfully chlorpyrifos could affect children. It also brought to light how hard the company would work to protect its lucrative pesticide. It soon became clear that Dow\u2019s strategy was to protect the public image of chlorpyrifos, heavily promoting the most positive view of its chemical and attacking research to the contrary.<\/p>\n<p>During the discovery process of the Herb case, Calwell asked Dow\u2019s lawyers to provide reports of adverse incidents tied to the chemical, which companies are required by law to file with the Environmental Protection Agency. Dow\u2019s attorneys told him to get the reports directly from the EPA, according to Calwell. But a judge backed Calwell\u2019s request, and Dow was forced to hand over 220 reports of adverse incidents, including poisonings, that it hadn\u2019t filed with the agency. Calwell, who went on to litigate several cases of people exposed to chlorpyrifos, still remembers the day the Dow attorneys showed up in court holding the brown envelope full of the reports.<\/p>\n<p>While Dow was keeping some of the disturbing information about its chemical from the public, its own research was showing chlorpyrifos to be much safer. While they were reassuring, the company\u2019s studies were also \u201cscientifically worthless,\u201d according to neuroscientist and Stanford professor Robert Sapolsky. Calwell hired Sapolsky, an expert in the degeneration of nerve cells and a recipient of a MacArthur Fellowship, to review Dow\u2019s own studies on the pesticide. After reading them, Sapolsky wrote to me in an email, he was \u201csimply stunned at how bad the work was, how utterly awful every aspect of them was, from the scholarship to how the studies were conducted to how data were analyzed, to how everything was then interpreted.\u201d<\/p>\n<p>Eventually, Sapolsky enlisted a dozen postdoctoral neuroscientists at Stanford to systematically review as much of the company\u2019s research on the pesticide as he could find. According to an unpublished <a target=\"_blank\" href=\"https:\/\/www.documentcloud.org\/documents\/3288787-Sapolsky.html\" >report<\/a>\u00a0they produced in 2008-2009, all the Dow studies on chlorpyrifos they reviewed had some errors and 89 percent had errors that broke the basic rules of science. And these weren\u2019t randomly distributed mistakes, according to Sapolsky. \u201cEvery one of the errors in the papers worked in Dow\u2019s favor.\u201d Thus tailored, the company\u2019s studies \u201cwere all sterling testimonies to [the] utter safety of the stuff,\u201d according to the neuroscientist.<\/p>\n<p>Dow heavily promoted this rosy vision of chlorpyrifos. Even as it was spinning the science, collecting reports of poisoning incidents, and fending off legal responsibility for them, Dow \u2014 or Dowelanco, as it was called at the time \u2014 was also boasting about the safety of its pesticide. \u201cThe 20-plus years of chlorpyrifos use involving millions of applications confirm that there is not a single documented incident of significant adverse health effect resulting from proper use of Dursban insecticides,\u201d announced one 1991 brochure under a picture of a woman with a small child on her lap. \u201cDoes Dursban have any long-term effects?\u201d the brochure asked before supplying the answer: \u201cNo.\u201d<\/p>\n<p>Such assertions were, even back then, patently untrue, as the New York attorney general argued in a 1993 suit charging the company with false advertising. Citing the dangers of pesticides and the particular risks they posed to children, the settlement of the case required Dowelanco to immediately stop using such language to promote its chlorpyrifos-containing products, Dursban and Lorsban.<\/p>\n<p>But Dow stuck to its claims of safety, even when they put the company at odds with the truth \u2014 and the law. Almost immediately after striking an agreement over the first suit from the New York attorney general, Dow went on to violate it with more falsely reassuring claims about chlorpyrifos, according to another suit from the AG\u2019s office. Dow paid $2 million to <a target=\"_blank\" href=\"https:\/\/ag.ny.gov\/press-release\/dow-subsidiary-pay-2-million-making-false-safety-claims-pesticide-ads\" >settle that suit<\/a> in 2003. For the AG\u2019s office, this was a record fine. For Dow, it was perhaps a small price to pay for a decade\u2019s worth of reassuring messaging.<\/p>\n<p>The legal challenges cost the company only modestly. Dow settled several of the poisoning cases and reportedly paid Joshua Herb\u2019s family $10 million, which helped cover Joshua\u2019s round-the-clock care. And Calwell\u2019s discovery that Dow had withheld critical information about its chemical led to the EPA fining the company $876,000 in 1995. But the company never admitted any wrongdoing, even in the case of Joshua Herb, who died as a teenager.<\/p>\n<div id=\"attachment_85512\" style=\"width: 710px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ4.jpg\" ><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-85512\" class=\"wp-image-85512\" src=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ4.jpg\" width=\"700\" height=\"443\" srcset=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ4.jpg 1000w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ4-300x190.jpg 300w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ4-768x486.jpg 768w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><p id=\"caption-attachment-85512\" class=\"wp-caption-text\">A view of the farms across the street from the neighborhood Eva Galindo grew up in, photographed on Dec. 29, 2016, in Salida, Calif. Photo: Shaun Lucas for The Intercept<\/p><\/div>\n<p>By the late 1990s, when\u00a0Dow was negotiating with the EPA over chlorpyrifos, more than 10 million pounds of the pesticide were <a target=\"_blank\" href=\"https:\/\/water.usgs.gov\/nawqa\/pnsp\/usage\/maps\/show_map.php?year=2000&amp;map=CHLORPYRIFOS&amp;hilo=L\" >used<\/a> on crops each year. In 2000,\u00a0advocacy groups including Beyond Pesticides and Californians for Pesticide Reform asked the EPA to ban the chemical\u00a0altogether, including its use in agriculture. But Dow threatened to sue the agency if it tried for a full ban, according to a retired EPA toxicologist named Jeremy Blondell.<\/p>\n<p>\u201cThey negotiated with us and said, fine, we won\u2019t take you to court,\u201d Blondell explained in an interview. The prospect of a long, expensive legal battle apparently deterred the agency from moving forward. \u201cIf we had gone to court, it would have taken four or five years,\u201d said Blondell. Instead,\u00a0in 2000 the agency struck an\u00a0agreement with Dow that phased out most household uses of chlorpyrifos but\u00a0preserved\u00a0the growing agricultural market from serious restrictions.<\/p>\n<p>A few years earlier, Dow had managed an even bigger threat to its pesticides. As the biggest spender in a coalition of companies, Dow actively <a target=\"_blank\" href=\"https:\/\/cloudfront-files-1.publicintegrity.org\/legacy_projects\/pdf_reports\/UNREASONABLERISK.pdf\" >fought<\/a> the implementation of a clause in a 1958 law that had strictly forbidden the use of food additives that caused any cancer in humans or animals. Dozens of pesticides could have been outlawed if it were enforced. Instead, by 1996, Dow led a coalition that helped water down the strict \u201czero risk\u201d standard set by the law to one designed to minimize the risk to health.<\/p>\n<p>It fell to the EPA to calculate how much risk to health was acceptable based on the risk of <a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1253789\/\" >cancer<\/a> and other diseases. As it does with <a target=\"_blank\" href=\"https:\/\/theintercept.com\/2016\/05\/17\/new-evidence-about-the-dangers-of-monsantos-roundup\/\" >most pesticides<\/a>, the agency used the company\u2019s own studies to determine safety for humans, including some of those Sapolsky had judged as flawed and biased. In 1996, when the agency re-registered chlorpyrifos, the EPA set a safety limit that allowed the chemical to be used in amounts that caused just a small reduction in the activity of the enzyme cholinesterase. For <a target=\"_blank\" href=\"https:\/\/www.nrdc.org\/experts\/jennifer-sass\/highly-hazardous-pesticide-chlorpyrifos-doesnt-look-so-bad-when-i-wear-my-epa\" >kids<\/a>, it soon became clear, this wasn\u2019t enough.<\/p>\n<p>It\u2019s standard practice for companies to rely on animal studies to prove the safety of their chemical products. Conducted in research labs, such experiments allow scientists to closely control and monitor their conditions, pinpoint the exact doses associated with outcomes, and replicate entire studies. But different species don\u2019t always respond to chemicals the same way. And, while scientists have traditionally tested the safety of pesticides by exposing lab animals to relatively high doses, such studies don\u2019t necessarily capture the risks posed by the lower amounts people breathe and eat.<\/p>\n<p>In 1998, when Dow was still facing off with victims in court, three teams of scientists began to tackle the questions of how these real-world exposures affect actual people. At the University of California, Berkeley and Mt. Sinai Hospital and Columbia University in New York City, the researchers embarked on a series of government-funded studies to see how young children were affected by environmental chemicals.<\/p>\n<p>Virginia Rauh, an epidemiologist leading the neurodevelopment team at the Columbia\u00a0Center for Children\u2019s Environmental Health, chose to investigate chlorpyrifos because she and her colleagues were aware\u00a0that organophosphate pesticides had potentially irreversible neurological effects on lab animals. She also knew that the chlorpyrifos could cross the human placenta and enter the fetal blood before birth. Plus, as she explained to me recently in her office overlooking the Hudson River, \u201cthese are chemicals that were specifically designed to attack the mammalian nervous system.\u201d<\/p>\n<p>Rauh and her colleagues, who ultimately enrolled 725 African-American and Dominican mothers and their children in New York City, were aware, too, that like most New Yorkers, the women in the Columbia\u00a0study used the stuff to kill fleas, ants, and cockroaches in their homes.<\/p>\n<p>As she expected, the research team\u00a0soon found ample evidence of chlorpyrifos exposure. Ninety-nine percent of the air\u00a0sampled from the\u00a0subjects\u2019\u00a0apartments tested\u00a0<a target=\"_blank\" href=\"http:\/\/www.niehs.nih.gov\/research\/supported\/translational\/peph\/webinars\/neurodevelopment\/brain_and_behavioral_effects_of_prenatal_exposure_to_a_widely_used_pesticide_508.pdf\" >positive<\/a> for chlorpyrifos, as did\u00a070 percent of the blood samples taken from the mothers and their children. What Rauh hadn\u2019t expected was that the EPA\u2019s ban on in-home use of chlorpyrifos would go into effect in 2001, even as the team\u00a0was enrolling women in the study, almost immediately causing the amounts\u00a0of the chemical in their bodies to drop. \u201cWe have this beautiful slide that shows the concentration levels going down right after the ban, and by 2006, almost all the levels were nondetectable,\u201d Rauh told me.<\/p>\n<p>This accident of timing divided her study population into two: children who were born before the ban, and had relatively high levels of exposure, and those born afterward, whose levels were much lower. When the Columbia researchers\u00a0compared the otherwise indistinguishable groups, they\u00a0found clear differences. The babies who were exposed to more of the chemical tended to be smaller, have <a target=\"_blank\" href=\"https:\/\/archive.epa.gov\/scipoly\/sap\/meetings\/web\/pdf\/rauh.pdf\" >poorer reflexes<\/a>, and weigh less. In fact, the babies with the highest level of chlorpyrifos were a half-pound lighter on average than those with the lowest levels.<\/p>\n<p>What\u2019s more, even though the exposures happened before birth, their effects seemed to last for years. Rauh and her colleagues kept following the children enrolled in the study and found that, at age 3, those who had higher chlorpyrifos levels were more likely to lag in terms of both motor and mental development. The differences weren\u2019t subtle. The children in the higher exposure group were more than twice as likely to be mentally delayed; more than <a target=\"_blank\" href=\"https:\/\/archive.epa.gov\/scipoly\/sap\/meetings\/web\/pdf\/rauh.pdf\" >five times as likely<\/a> to have symptoms of pervasive developmental disorder, a diagnosis that was later folded into autism spectrum disorder; more than six times as likely to have ADHD-type symptoms; and more than 11 times as likely to have symptoms of other attention disorders.<\/p>\n<p><a href=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ5.jpg\" ><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-85513\" src=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ5-1024x807.jpg\" width=\"500\" height=\"394\" srcset=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ5.jpg 1024w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ5-300x236.jpg 300w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ5-768x605.jpg 768w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/a><\/p>\n<p>Meanwhile, the team out in Berkeley was also <a target=\"_blank\" href=\"http:\/\/cerch.berkeley.edu\/resources\/environmental-exposures\" >tying<\/a> chlorpyrifos exposure to a number of neurodevelopmental effects, as the researchers from both teams discovered when they met up at a conference. The Berkeley study, known as <a target=\"_blank\" href=\"http:\/\/cerch.org\/research-programs\/chamacos\/\" >CHAMACOS<\/a> (for the Center for the Health Assessment of Mothers and Children of Salinas), was studying women and children in California\u2019s rural farming communities. Their findings were strikingly similar to what Rauh had found in an urban setting. When compared to the children with the lowest prenatal exposures, the CHAMACOS kids who had been most highly exposed also tended to have lower IQs, poorer cognitive function, abnormal reflexes, and an increased risk of attention problems.<\/p>\n<p>And when they followed the kids in their study as they aged, both teams found that the effects <a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3237355\/\" >persisted<\/a>. At age 7, the highly exposed children in Rauh\u2019s sample had lower IQs and deficits in working memory. The team in Berkeley also found that exposure to organophosphates had\u00a0<a target=\"_blank\" href=\"http:\/\/ehp.niehs.nih.gov\/1003185\/\" >significant lasting effects<\/a>. In their group, 7-year-olds who had the highest level of exposure to organophosphate pesticides, including chlorpyrifos, had IQ scores that were seven points lower than those with the lowest exposure.<\/p>\n<p>The researchers at Mt. Sinai had similar findings. In fact, all three groups of scientists studying chlorpyrifos were so similar that they decided to publish them together. Each one had independently found that chlorpyrifos had neurodevelopmental effects on children. Perhaps most startlingly, the researchers were seeing effects at levels of chlorpyrifos lower than the ones that interfered with cholinesterase. In Rauh\u2019s study, the pesticide had lasting effects on kids\u2019 brains at levels <a target=\"_blank\" href=\"https:\/\/www.nrdc.org\/experts\/jennifer-sass\/highly-hazardous-pesticide-chlorpyrifos-doesnt-look-so-bad-when-i-wear-my-epa\" >20 times below<\/a>\u00a0the EPA\u2019s safety level.<\/p>\n<p>Dow, which often refers to Rauh\u2019s work as \u201ccontroversial,\u201d has taken issue with her findings precisely because they show that small amounts of the chemical can have effects. <a target=\"_blank\" href=\"https:\/\/theintercept.com\/2017\/01\/14\/dow-chemical-wants-farmers-to-keep-using-a-pesticide-linked-to-autism-and-adhd\/www.chlorpyrifos.com\" >Chlorpyrifos.com<\/a>, a website created by the company, cites the fact that the Columbia study\u2019s thresholds are lower than those of other studies as one of the reasons the effects \u201care not likely to have been caused by chlorpyrifos.\u201d<\/p>\n<p>The company\u2019s own studies, which the site describes as \u201c40 years of high-quality animal research,\u201d were not looking for the changes Rauh observed and couldn\u2019t have detected them because they were done on animals. Nor would it have been ethical to deliberately expose humans to brain-altering levels of chlorpyrifos. Yet just by using the pesticide in their homes, people were exposed to the chemicals at these levels. The epidemiologists were observing changes that took place as people encountered the pesticides in their daily lives.<\/p>\n<p>\u201cThese were relatively modest exposure levels,\u201d Rauh said. \u201cA lot of people in the country are still having these exposures.<\/p>\n<p>Zenaida Mu\u00f1oz likely had even higher exposures to chlorpyrifos when she was pregnant with her 8-year-old son, Alan. At the time, Mu\u00f1oz was living directly across the street from an orange grove in the central California town of Woodlake. Her one-story house was about 30 feet from the trees. And when the groves were sprayed, the fumes drifted in through the windows. Plus, one of her favorite ways to relax was to walk through the orange groves. She spent much of her free time during her pregnancy this way, wandering past the rows of perfectly spaced trees.<\/p>\n<p>Sometimes on her walks, the smell of the chemicals was strong enough to make Mu\u00f1oz nauseous. But at the time, it didn\u2019t occur to her that she \u2014 or the baby growing inside of her \u2014 might suffer any lasting effects. \u201cPesticides are a part of life here, they\u2019re normal,\u201d she told me through a translator. And, indeed, it is residents of agricultural communities like Woodlake who tend to have the highest exposure. A <a target=\"_blank\" href=\"http:\/\/www.panna.org\/press-release\/television-show-and-body-testing-confirm-children%E2%80%99s-exposure-neurotoxic-pesticide\" >documentary<\/a> filmmaker who recently analyzed hair samples from six children in farming communities in California found that each tested positive for at least 50\u00a0different pesticides, including chlorpyrifos. In addition to being exposed to the residues on fruits and vegetables, as people throughout the country are, they are more likely to inhale chlorpyrifos that drifts in the air after spraying and drink the small amounts of it that sometimes seep into drinking water. Like everyone else living around the grids of farmland that make up much of central California, Mu\u00f1oz was used to seeing workers spray the chemicals. And she assumed that if a chemical were truly dangerous, farmers wouldn\u2019t be allowed to use it.<\/p>\n<p>In the four years since Alan was diagnosed with autism and ADHD, Mu\u00f1oz has thought about those walks often. She knew her son was struggling long before then. Alan is her second child and at just 8\u00a0months of age, he already seemed far more restless and difficult than her first. He would run at every opportunity and never seemed to settle down. By the time he was 4, he was clearly far less able to speak than his peers. He also had a hard time making friends. His many frustrations led to sudden outbursts.<\/p>\n<p>Mu\u00f1oz, who moved to the nearby town of Cutler four years ago, knows other mothers whose children have health effects they believe are related to pesticides. She belongs to a group of 20 women who get together regularly to work on local issues. Four of them have children with neurodevelopmental problems, two have kids\u00a0with\u00a0ADHD, and one mom\u00a0described her 3-year-old daughter as having \u201cmental retardation and other cognitive problems.\u201d<\/p>\n<p>Now pregnant with a third child, Mu\u00f1oz tries to avoid exposure to pesticides. It\u2019s not easy. She stays indoors as much as possible and has stopped taking her walks through the orchards. But Mu\u00f1oz still passes them every day as she takes Alan to school. And even as he struggles, he continues to risk exposure to the pesticide. Alan\u2019s school, Cutler Elementary, is a short distance from the fields \u2014 as everything is in Cutler. California\u2019s careful tracking of the locations and quantities\u00a0of pesticide applications has shown that Alan is one of some 500,000 children in California who attend a school within a quarter mile of fields where \u201cpesticides of public health concern,\u201d such as chlorpyrifos, are applied.<\/p>\n<div id=\"attachment_85514\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ6.jpg\" ><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-85514\" class=\"wp-image-85514\" src=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ6-1024x685.jpg\" width=\"600\" height=\"401\" srcset=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ6-1024x685.jpg 1024w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ6-300x201.jpg 300w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ6-768x514.jpg 768w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ6.jpg 2000w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><p id=\"caption-attachment-85514\" class=\"wp-caption-text\">A \u201cDo Not Enter\u201d sign marks a field of head cabbage during the spraying of pesticides near Chualar, Calif., in 2002. Photo: Mike Fiala\/AP<\/p><\/div>\n<p>The science documenting that chlorpyrifos has long-term effects on children\u2019s brains had reached a critical mass by 2007. That year, Earthjustice sued the EPA on behalf of the Pesticide Action Network, the Natural Resources Defense Council, and farm worker groups, asking that it consider the long-term effects of chlorpyrifos and ban the chemical. That suit turned out to be the first of many. The EPA failed to take action, however, so\u00a0the environmental groups sued the agency again in 2010, urging it to stop all uses of chlorpyrifos. In 2012, when the EPA still hadn\u2019t banned the pesticide, the groups sued yet again, to no avail. And in September 2014, seven years after they first filed\u00a0their request, the advocates sued the EPA for a fourth time, again demanding that the agency revoke its approval of chlorpyrifos.<\/p>\n<p>Such delays are unfortunately typical of the process of getting dangerous pesticides off the market, according to Patti Goldman, an Earthjustice attorney who has been working on the chlorpyrifos suit. Part of the reason for the glacial pace, according to Goldman, is the influence of pesticide manufacturers.<\/p>\n<p>\u201cIndustry spends a lot of time walking the halls of EPA and urging the agency not to do anything until it\u2019s absolutely sure,\u201d said Goldman, who has noted an increased presence from Dow in recent years. Indeed, Dow, a multinational corporation that had more than $48 billion in revenue in 2015, has a far bigger budget for lobbying and scientific research than the nonprofit organizations representing the health interests of kids and farmworkers. \u201cThey can spend a lot of money on all of that,\u201d said Goldman. \u201cWe just don\u2019t have the resources.\u201d<\/p>\n<p>Nevertheless, three months after the groups\u2019 last suit, in December 2014, the EPA did what the smaller groups had been urging for years, acknowledging the serious risks chlorpyrifos posed to the developing brain. In a draft version of the risk assessment finalized in November, the agency highlighted Rauh\u2019s work showing an increased chance of developmental disorders, attention problems, working memory loss, and intelligence deficits in children who had been exposed to the pesticide prenatally. Still, the EPA did not move to take chlorpyrifos off the market.<\/p>\n<p>By August 2015, after the EPA requested yet another delay before issuing a final decision, the court that had been hearing the chlorpyrifos case reached the limit of its patience. <a target=\"_blank\" href=\"http:\/\/cdn.ca9.uscourts.gov\/datastore\/opinions\/2015\/08\/10\/14-72794.pdf\" >Calling<\/a> the delay in responding to the advocates\u2019 2007 petition \u201cegregious,\u201d three judges in the 9th Circuit Court gave the EPA a hard-and-fast deadline for finalizing its rule: October 31, 2015.<\/p>\n<p>In an emailed response to questions from The Intercept, a spokesperson for the EPA said the delay in responding to the groups\u2019 request was due to the fact that the suit \u201craised numerous complex, novel scientific issues,\u201d which required several scientific reviews. Those reviews, the agency representative wrote, \u201crequired years to complete, which is not unusual for cutting-edge scientific issues.\u201d<\/p>\n<p>Yet even with a clear timeline set, the EPA requested another extension. And, once it was granted, the agricultural lobby moved to prolong the process still further. In July 2016, 15 groups, including the American Sugarbeet Growers Association, the National Potato Council, the National Corn Growers Association, the American Soybean Association, the Almond Alliance of California, the National Cotton Council, the U.S. Apple Association, and CropLife America, an agribusiness trade association whose members include Dow, wrote to the court. Though the EPA had been considering banning chlorpyrifos for at least nine years, the groups insisted that they had been given \u201cnot nearly enough time\u201d to respond. The industry brief described the EPA as being \u201cforced to rush to judgment\u201d and argued that the agency\u00a0needed at least another year beyond the court\u2019s current deadline to conduct its science work.<\/p>\n<p>By this point, Dow had enlisted <a target=\"_blank\" href=\"http:\/\/www.exponent.com\/professionals\/r\/reiss-richard\" >Exponent<\/a>, a science-for-hire group, to publish <a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22446730\" >articles<\/a> disputing the accumulating science on chlorpyrifos and <a target=\"_blank\" href=\"https:\/\/theintercept.com\/2017\/01\/14\/dow-chemical-wants-farmers-to-keep-using-a-pesticide-linked-to-autism-and-adhd\/Finally,%20literature%20data%20show%20that%20brain%20AChEI%20is%20the%20appropriate%20metric%20for%20cholinesterase%20inhibition%20risk%20assessment%20for%20chlorpyrifos.\" >arguing<\/a> that there is no scientific reason to change the safety standards. Yet when those publications were excluded, the scientific literature overwhelmingly agreed about the harms of organophosphate pesticides, including chlorpyrifos. Of <a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24121005\" >27 studies<\/a> published by 2012, all but one showed that organophosphate pesticides\u00a0caused \u201cnegative effects\u201d in\u00a0children\u2019s brains. And since then, several others, including the CHARGE study, have added to the findings. Yet because the EPA cited Rauh\u2019s work most often in its decision to move forward on chlorpyrifos, the industry focused its attentions on the Columbia epidemiologist, dissecting her papers and criticizing the researcher herself.<\/p>\n<p>In addition to taking issue with its focus on humans, Dow has complained that the Columbia team has refused to make their data public. Rauh\u2019s \u201craw data have not been made available for independent scrutiny by EPA and other stakeholders, despite multiple requests from the agency to the study authors on previous occasions to provide it,\u201d the company claimed on <a target=\"_blank\" href=\"http:\/\/www.chlorpyrifos.com\/benefits-and-use\/\" >chlorpyrifos.com<\/a>.<\/p>\n<p>Dow has also made that charge in public comments to the EPA and in legal briefs submitted to the court. The industry talking point even surfaced in a February hearing on \u201cthe impacts of the Environmental Protection Agency\u2019s actions on the rural economy,\u201d when committee chair K. Michael Conaway said that he \u201cheard\u201d that Rauh\u2019s \u201cresearch data may not be reliable\u201d and that Columbia had \u201crefused to provide the raw data to EPA even though EPA provided funding for the study,\u201d according to his prepared comments.<\/p>\n<p style=\"padding-left: 30px;\"><strong><em>\u201cWe do the science, we publish the work, we release data when we\u2019re asked. Everything has been done appropriately.\u201d<\/em><\/strong><\/p>\n<p>In response to questions from The Intercept for this article, Dow AgroSciences said in a statement that the company \u201cstrongly disagrees with EPA\u2019s proposal to revoke chlorpyrifos tolerances.\u201d Dow also said\u00a0that the \u201cEPA\u2019s proposal to revoke all tolerances appears to be based on a non-replicated epidemiology study for which no raw data has been provided to the agency. Dow AgroSciences is confident\u00a0that authorized uses of chlorpyrifos products offer wide margins of protection for human health and safety, when used as directed.\u201d<\/p>\n<p>But when I asked the Rauh\u00a0herself whether she had shared her data with the EPA, she seemed familiar with and perplexed by the accusation. \u201cIt is hard to take seriously because it\u2019s not true,\u201d Rauh said with a sigh.\u00a0\u201cWe do the science, we publish the work, we release data when we\u2019re asked. Everything has been done appropriately.\u201d<\/p>\n<p>Rauh said she and other researchers on her team have had several meetings with EPA officials. \u201cEPA has been invited to have our data. They don\u2019t even want it. There is no contentiousness about it. They\u2019ve seen it, it\u2019s been represented to them many, many times.\u201d When asked whether Rauh had refused to provide data, the EPA referred to a note the agency inserted into the public record in 2014 saying\u00a0that while the agency had initially requested the raw data from the Columbia Center for Children\u2019s Environmental Health, and the center \u201cdid not agree to provide\u201d them, subsequently \u201cthe researchers met with EPA and discussed the agency\u2019s questions about the data to help determine whether further review of the raw data might assist EPA in resolving uncertainties. As a result of new information gathered through an on-site meeting and other sources, EPA is no longer pursuing the request for the original analytic data file from CCCEH researchers.\u201d<\/p>\n<p>The Columbia epidemiologist knows her work has drawn the ire of industry. \u201cThey have an army,\u201d Rauh said of the many scientists Dow has hired to focus on her work. She gets questioning emails from them every time she publishes a paper, and she has seen them at meetings, when \u201cDow had booked most of the day with their rebuttals trying to poke holes.\u201d But Rauh chooses not to engage directly with her detractors. Instead, she pointed to the dozens of studies beyond her own showing links between early chlorpyrifos exposure and neurodevelopmental problems, noting, \u201cThe evidence is mounting and it is largely consistent.\u201d The EPA\u2019s new report backs her up, finding that with the exception of two negative studies in 2015, \u201call other study authors have identified significant associations with neurodevelopmental outcomes.\u201d<\/p>\n<p>Perhaps the most impressive recent addition to the science on chlorpyrifos is\u00a0the CHARGE study, in which Eva Galindo participated. Directed by epidemiologist Irva Hertz-Picciotto, CHARGE looks at both genetic and environmental factors in the development of autism and has helped establish links between autism and insufficient folic acid intake as well as the presence of metabolic conditions, such as diabetes, obesity, and hypertension, in mothers.<\/p>\n<p>In 2014, the CHARGE researchers added pesticides to their\u00a0list of environmental factors linked to the disease with a study of nearly 1,000 children, including 486 with autism spectrum disorder. <a target=\"_blank\" href=\"http:\/\/ehp.niehs.nih.gov\/wp-content\/uploads\/122\/10\/ehp.1307044.alt.pdf\" >Published<\/a> in Environmental Health Perspectives in 2014, the paper showed that the children born to women who lived near agricultural fields where pesticides were applied during their pregnancies have significantly higher rates of autism.<\/p>\n<p>Several organophosphates besides chlorpyrifos were associated with increased autism rates, as were another group of pesticides called pyrethroids. And other kinds of developmental delay were also associated with the pesticides. But the link between autism and chlorpyrifos was the strongest. While the nationwide autism rate is now one in 68, for women who lived near fields where chlorpyrifos was sprayed during their second trimester, the chance of having a child with autism was closer to one in 21.<\/p>\n<p>Hertz-Picciotto, who came to the MIND (Medical Investigations of Neurodevelopmental Disorders)\u00a0Institute at the University of California\u2013Davis from North Carolina in 2001, was able to zero\u00a0in on the connection because of California\u2019s records on both pesticide use and autism cases, which are both the most detailed in the nation. After identifying the children with autism, she interviewed mothers about where they were living during their pregnancies and combined that information with the data on where pesticide spraying took place.<\/p>\n<p>Her efforts came at a delicate time. Since the idea that vaccines cause autism was first hotly debated and then <a target=\"_blank\" href=\"http:\/\/www.thetimes.co.uk\/tto\/health\/article1879347.ece\" >discredited<\/a> over the last decade, the public has come to distrust experts who focus on environmental causes of the developmental disorder. \u201cThere\u2019s this culture in science that favors the most technologically advanced approach over anything else,\u201d said Hertz-Picciotto. \u201cBecause of this molecular revolution, genetics has taken center stage in a huge way. If you look at NIH funding [for research on the causes of autism], comparing genetics versus environmental factors, the ratio is 20 to 1.\u201d<\/p>\n<p>But Hertz-Picciotto, whose previous work focused on the impact of lead on children, feels it\u2019s pointless to pit genetic and environmental factors against one another. Both contribute to the development of the disease roughly equally, she said, and even interact. Several studies have shown particular <a target=\"_blank\" href=\"http:\/\/ehp.niehs.nih.gov\/0900870\/\" >genetic variations<\/a> increase the susceptibility of both children and adults to chlorpyrifos, for instance. And several different genetic and environmental occurrences may contribute to any one case of the disease.<\/p>\n<p>\u201cI suspect that there are multiple factors,\u201d said Hertz-Picciotto. \u201cMaybe not taking your prenatal vitamin doesn\u2019t push you over the edge, it just creates the susceptibility. Maybe then the mom got an illness. Maybe she had a little flu. And that also had some impact on the migration of cells getting to the right place in the brain. \u2026\u00a0Of course, the body, even before birth, has some resilience. However, pesticides like many other chemicals, cross the placenta, and the fetus has fewer enzymes to detoxify chemicals than a child or adult has; and finally after a certain point, the insults pile up and you\u2019ve gone past the ability \u2014 the biologic capacity \u2014 \u00a0to adapt.\u201d<\/p>\n<p>Chlorpyrifos exposure is just one of several chance occurrences that may combine to cause autism. But unlike an individual\u2019s genetic makeup, it\u2019s one that could be easily changed. That, according to Hertz-Picciotto, is the appeal of exploring the environmental causes of autism. While genetic research may, in the long term, help to develop\u00a0treatments for autism, exploring the environmental triggers for the disease can help prevent future cases.<\/p>\n<div id=\"attachment_85515\" style=\"width: 410px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ7.jpg\" ><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-85515\" class=\"wp-image-85515\" src=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ7-1024x687.jpg\" width=\"400\" height=\"268\" srcset=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ7-1024x687.jpg 1024w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ7-300x201.jpg 300w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ7-768x515.jpg 768w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ7.jpg 2000w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><p id=\"caption-attachment-85515\" class=\"wp-caption-text\">Jennifer Coleman cleans up in the kitchen after dinner on Dec. 29, 2016, in Modesto, Calif.<br \/> Photo: Shaun Lucas for The Intercept<\/p><\/div>\n<p>Jennifer and Patrick Coleman took part in the CHARGE study for that very reason \u2014 because they hoped it might prevent other kids from developing autism and spare other parents some of the difficulties their family has endured. \u201cIt\u2019s too late for us, we already have it,\u201d Jennifer Coleman told me recently. By \u201cwe\u201d Coleman meant her two sons, Jackson, who is 12, and his little brother, Drake, who is 7.<\/p>\n<p>Caring for her children\u00a0is clearly more time-consuming and labor-intensive than it would be if they didn\u2019t have autism. Drake also has ADHD, and the boys\u2019 behavior can be unpredictable and grating, their meltdowns frequent and loud.<\/p>\n<p>\u201cEverything about parenting is harder,\u201d Jennifer told me as we sat in their leafy backyard in Modesto, California. Both boys were actually playing quietly at the time, but \u201cother parents can tell their kids, \u2018Don\u2019t do that,\u2019 and they won\u2019t do that. My kids are like, \u2018What?\u2019 When you say, \u2018Don\u2019t do it,\u2019 my kids will do it 12,000 more times.\u201d<\/p>\n<p>Parenting can also be more emotionally wrenching in ways that are impossible to measure. There is Patrick Coleman\u2019s sadness that Jackson will never be an Eagle Scout, for instance, or his fear that Drake\u2019s wildness will ultimately land him in prison. Even the prospect of telling Jackson the truth about Santa has thrown his parents into a terror most parents of neurotypical children will never know. He still believes \u201clock, stock, and barrel,\u201d as his mother put it, and they fear he will see their years of misinformation as an unforgivable betrayal.<\/p>\n<p>Indeed, while he is a literal-minded child, Jackson is also an exquisitely sensitive one. After he was recently bullied at school by kids who find him odd, Jackson told his mother in a matter-of-fact tone that he wanted to die. Jennifer Coleman was able to get her son transferred to another class and he now seems happier. But she knows both her sons will continue to struggle \u2014 and that there is little she can do besides being as loving and patient a parent as she can be \u2014 and participating in research that might spare other kids and parents the same fate.<\/p>\n<div id=\"attachment_85516\" style=\"width: 410px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ8.jpg\" ><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-85516\" class=\"wp-image-85516\" src=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ8-1024x683.jpg\" width=\"400\" height=\"267\" srcset=\"https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ8-1024x683.jpg 1024w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ8-300x200.jpg 300w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ8-768x512.jpg 768w, https:\/\/www.transcend.org\/tms\/wp-content\/uploads\/2017\/01\/pesticides-autism-dow-chemical-environ8.jpg 1440w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><p id=\"caption-attachment-85516\" class=\"wp-caption-text\">Jackson Coleman plays in his living room.<br \/> Photo: Shaun Lucas for The Intercept<\/p><\/div>\n<p>The EPA, on the other hand, has the power to ban\u00a0chlorpyrifos. By law, the agency is required to regularly re-evaluate pesticides to make sure they continue to meet the safety standard of causing \u201c<a target=\"_blank\" href=\"https:\/\/www.epa.gov\/pesticide-reevaluation\/why-we-review-pesticides\" >no adverse effects<\/a>.\u201d And in its infuriatingly slow way, the agency was doing what it was supposed to do.\u00a0The EPA\u2019s November 10 report showed that despite the intense pressures of the industry, the agency has come to see the dangers of chlorpyrifos as settled science. It was taking action, and had the election gone differently \u2014 or had the EPA not requested its final extension of its deadline \u2014 the policy may have been settled, too.<\/p>\n<p>Instead, the chemical industry has renewed its efforts to derail the proposed regulation. On November 29, CropLife America launched a <a target=\"_blank\" href=\"http:\/\/191hmt1pr08amfq62276etw2.wpengine.netdna-cdn.com\/wp-content\/uploads\/2016\/01\/FINAL-CLA-Petition-Regulatory-Decision-Making-11-29-16.pdf\" >Hail Mary effort<\/a> to stop the ban. The business group <a target=\"_blank\" href=\"http:\/\/191hmt1pr08amfq62276etw2.wpengine.netdna-cdn.com\/wp-content\/uploads\/2016\/01\/FINAL-CLA-Petition-Regulatory-Decision-Making-11-29-16.pdf\" >petitioned<\/a> the head of the office of pesticide programs to \u201ccease regulatory decision making\u201d on chlorpyrifos until it has developed standards \u201cfor acceptance of epidemiologic studies in human health risk assessment,\u201d a process that could easily take several years.<\/p>\n<p>Donald Trump\u2019s scorn for science and his embrace of <a target=\"_blank\" href=\"https:\/\/www.washingtonpost.com\/opinions\/trumps-news-source-alien-lizards-fluoride-mind-control-and-voter-fraud\/2016\/11\/28\/c0326c26-b5a0-11e6-b8df-600bd9d38a02_story.html?utm_term=.820eb6b553ba\" >widely discredited ideas<\/a>, including the theory that <a target=\"_blank\" href=\"http:\/\/www.independent.co.uk\/news\/world\/americas\/donald-trump-says-vaccinations-are-causing-an-autism-epidemic-10505087.html\" >vaccines cause autism<\/a>, has long <a target=\"_blank\" href=\"https:\/\/www.washingtonpost.com\/news\/speaking-of-science\/wp\/2016\/11\/30\/scientists-are-really-really-worried-about-donald-trump\/?utm_term=.448dee038cf3\" >terrified<\/a> the scientific community. For those working on chlorpyrifos, that terror is sometimes accompanied by a feeling of destabilization. \u201cWe\u2019re all wondering what will happen next,\u201d said Nathan Donley, a senior scientist at the Center for Biological Diversity, who has studied chlorpyrifos. \u201cThat\u2019s what keeps me awake at night.\u201d<\/p>\n<p>Donley told me he thought the industry might have been emboldened by Trump. And it\u2019s easy to see why they might be. In the first months since the election, Trump has reinforced his allegiance to industry in general and Dow in particular. Mike McKenna, a Dow\u00a0lobbyist, was one of the first to serve on his transition team and Myron Ebell, a foe of chemical regulation who has received money from Dow, has overseen staffing of the new EPA. In December, Trump named Dow\u2019s CEO Andrew Liveris to head the American Manufacturing Council, a private sector committee that advises the secretary of commerce. Meanwhile, Scott Pruitt, Trump\u2019s pick to run the EPA, is an avowed foe of environment regulation.<\/p>\n<p>Dow has already managed to slow the process of regulating chlorpyrifos to a virtual crawl over the past decades. Could a process that\u2019s been thwarted by at least two previous administrations finally succeed under Trump?<\/p>\n<p>Some longtime advocates are clinging to the hope that the pending regulation is too far along for the new administration to stop. Disregarding the mountain of scientific evidence would be too egregious a move even for Trump, according to Patti Goldman, the Earthjustice attorney who has worked to protect the public from the effects of chlorpyrifos for more than 20 years.<\/p>\n<p>Though he is an unabashed friend of the chemical industry, the president-elect doesn\u2019t necessarily want to be an enemy of children, said Goldman. And choosing to ignore widely accepted research showing that a chemical hurts children\u2019s brains would make him just that. \u201cGoing up against brain damage in kids,\u201d she predicted, would be \u201ca public relations disaster.\u201d<\/p>\n<p>And then there\u2019s the matter of the law. The court\u2019s clear instruction to the EPA to issue its final rule on chlorpyrifos would be extremely difficult to defy, said Kristin Schafer, policy director of the Pesticide Action Network. \u201cThis is a legal deadline.\u201d<\/p>\n<p>But the company has several potential ways it could circumvent the regulation without technically defying the law. Dow recently previewed one in a <a target=\"_blank\" href=\"https:\/\/www.dowagro.com\/en-us\/newsroom\/pressreleases\/2016\/11\/dow-agrosciences-us-farmers-disagree-with-us-epa-proposal--to-revoke-chlorpyrifos-tolerances#.WEWalKIrLYI\" >press release<\/a> issued on the day the EPA announced the proposed ban. \u201cThe court ordered EPA to make a final decision on the petition by March 31, 2017, but did not specify what that decision should be,\u201d Dow explained. \u201cThe EPA can deny the petition and retain all tolerances, which would be consistent with the science and allow the agency to complete its registration review and address their remaining concerns in an orderly manner.\u201d In other words, the EPA could issue a rule that, despite the evidence, declares chlorpyrifos safe to use rather than moving forward with the ban. Or Congress could even draft legislation that somehow gives Dow\u2019s neurotoxic product a reprieve.<\/p>\n<p>Dow has been working on end-runs around the EPA since at least 2014, when the company hired <a target=\"_blank\" href=\"https:\/\/www.opensecrets.org\/lobby\/clientissues_spec.php?id=D000000188&amp;year=2016&amp;spec=ENV\" >lobbyist<\/a> James Callan to work on\u00a0\u201cfederal regulatory actions to maintain tolerances for the insecticide chlorpyrifos.\u201d The company has paid Callan $140,000 in the past two years, according to lobbying records.<\/p>\n<p>Just two years ago, when Callan first started working on chlorpyrifos, these strategies must have seemed like pipe dreams. At the time, the company\u2019s best option \u2014 its only option, really \u2014 was delay. Though a <a target=\"_blank\" href=\"https:\/\/www.nrdc.org\/sites\/default\/files\/IrisDelayReport.pdf\" >favored strategy<\/a> of the chemical industry, it was unclear that stalling action on chlorpyrifos would do anything more than extend the period in which the company could benefit from its product before an inevitable ban.<\/p>\n<p>After the whiplashing election, however, it\u2019s clear that Dow\u2019s bid for additional time may deliver much more, not just temporarily putting off a ban of chlorpyrifos but potentially setting the science-driven process back by years.<\/p>\n<p>Dow has done its best to quantify the benefits of its product, which, along with other pesticides, helps \u201cU.S. farmers produce 144 billion pounds of additional food, feed and fiber and reap $22.9 billion in farm income increases,\u201d according to chlorprifos.com. But the cost of continuing to use the toxin on our food can be measured, too. Every day chlorpyrifos is in use, more kids will be exposed \u2014 and more brains altered by the chemical. The oldest of the children in Rauh\u2019s study are now 18. And, as they age, she is learning more about how their brains are different. She recently scanned the brains of 20 of the children in her study and found structural differences in those who were most highly exposed. These kids also tend to have tremors and Rauh is now exploring whether they\u2019re more likely to develop parkinsonian-type symptoms as they enter late adolescence and adulthood.<\/p>\n<p>Several scientists have attempted to estimate the cost of the \u201c<a target=\"_blank\" href=\"http:\/\/www.thelancet.com\/journals\/laneur\/article\/PIIS1474-4422%2813%2970278-3\/abstract\" >silent pandemic of neurotoxicity<\/a>\u201d that\u2019s resulted from this and other toxic exposures. The TENDR scientists noted that chemicals, including chlorpyrifos, have already contributed to an \u201calarming increase in learning and behavioral problems in children.\u201d An estimated 10 percent of\u00a0American children are\u00a0now diagnosed with ADHD, and one in 68 American children is diagnosed with autism spectrum disorder, amounting to a 17 percent increase over the last decade.<\/p>\n<p>David Bellinger, a researcher at Harvard Medical School, sliced the burden another way, <a target=\"_blank\" href=\"http:\/\/ehp.niehs.nih.gov\/wp-content\/uploads\/120\/4\/ehp.1104170.pdf\" >estimating<\/a> that exposure to organophosphate pesticides, including chlorpyrifos, has collectively cost American children almost 17 million IQ points. In Europe, researchers have even tried to put a price tag on the neurodevelopmental problems caused by chlorpyrifos and other pesticides each year: 120 billion euros, or $126 billion.<\/p>\n<p>While children in farming communities get the biggest doses of chlorpyrifos, people across the country are exposed to potentially dangerous amounts of the chemical through their food. Though it\u2019s unclear exactly how much pesticide residue can alter brain development, all of the researchers I spoke with told me they advise pregnant women and young children to eat organic fruits and vegetables.<\/p>\n<p>It\u2019s not unlike the strategy of Zenaida Mu\u00f1oz, who has cloistered herself in her two-bedroom house in Cutler, California, during her pregnancy. After reckoning with the shock that chlorpyrifos could be used even though it\u2019s known to harm kids\u2019 brains, Mu\u00f1oz has done what she can to protect her growing family. They can\u2019t afford to buy organic. So, she\u2019s hoping her drawn curtains and closed doors will protect her \u2014 and waiting for the government to do something about the pesticide that is all around her.<\/p>\n<p><strong>______________________________________________<\/strong><\/p>\n<p style=\"padding-left: 30px;\"><em><a target=\"_blank\" href=\"https:\/\/theintercept.com\/staff\/sharon-lerner\/\" >Sharon Lerner<\/a> &#8211; <a href=\"mailto:sharon.lerner@theintercept.com\">\u2709sharon.lerner@\u200btheintercept.com<\/a><\/em><\/p>\n<p><em>Update: January 14, 2016: <\/em><em>This article was updated to clarify the descriptions of Virginia Rauh\u2019s and\u00a0Irva Hertz-Picciotto\u2019s research.<\/em><\/p>\n<p><em>This article was reported in partnership with The Investigative Fund at The Nation Institute.<\/em><\/p>\n<p><a target=\"_blank\" href=\"https:\/\/theintercept.com\/2017\/01\/14\/dow-chemical-wants-farmers-to-keep-using-a-pesticide-linked-to-autism-and-adhd\/\" >Go to Original \u2013 theintercept.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>While children in farming communities get the biggest doses of chlorpyrifos, people across the country are exposed to potentially dangerous amounts of the chemical through their food. Though it\u2019s unclear exactly how much pesticide residue can alter brain development, all of the researchers I spoke with told me they advise pregnant women and young children to eat organic fruits and vegetables.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[61],"tags":[],"class_list":["post-85508","post","type-post","status-publish","format-standard","hentry","category-environment"],"_links":{"self":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/posts\/85508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/comments?post=85508"}],"version-history":[{"count":0,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/posts\/85508\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/media?parent=85508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/categories?post=85508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.transcend.org\/tms\/wp-json\/wp\/v2\/tags?post=85508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}